Five years after saving the Queen, Dr. John Dolittle (Robert Downey Jr.) has transformed his sanctuary into a global refuge for animals of every kind. Peaceful. Purposeful. Until a desperate message echoes from deep within the uncharted Amazon rainforest — sent by a creature believed to be extinct.
Answering the call, Dolittle laces up his boots once more.
Joined by Tommy Stubbins (Harry Collett), now a capable explorer in his own right, and his unforgettable crew of talking animals — Poly the sharp-tongued parrot (Emma Thompson) and Chee-Chee the perpetually anxious gorilla (Rami Malek) — Dolittle ventures into the unknown in search of the legendary “Heart of the Wild,” a mythical source of nature’s ancient magic.
But the jungle isn’t unclaimed. A ruthless biotech tycoon is cutting a violent path through the forest, determined to exploit its secrets for power and profit.